2019 Fiscal Year Final Research Report
Functional collagen device for cartilage defect repair and regeneration
| Project/Area Number |
17K10965
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
MYOUI Akira 大阪大学, 医学部附属病院, 教授 (10263261)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岡本 美奈 大阪大学, 医学部附属病院, 助教 (50457008)
吉川 秀樹 大阪大学, 医学系研究科, 理事・副学長 (60191558)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Keywords | ウロコ由来Ⅰ型コラーゲン / 軟骨再生 / 高強度コラーゲン膜/コラーゲン多孔体複合デバイス |
|---|
| Outline of Final Research Achievements |
Fish scale-derived type I collagen has the unique feature of being able to reproduce the same fibrous structure as biological tissue. It is extremely strong compared to conventional collagen-derived biomaterial and highly promotes cell differentiation. It also has workability to be prepared as sponge-like structure, sheet-like, etc. We examined the utility of this new biomaterial in the treatment of cartilage lesions. Our results suggest its usefullness as a highly safe and high-strength cell-free cartilage defect repair material and also as a scaffold for cartilage regeneration products.
|
| Free Research Field |
整形外科学
|
| Academic Significance and Societal Importance of the Research Achievements |
軟骨欠損のセルフリー修復材料はこれまでに開発されておらず、本マテリアルは生体親和性が高く、有用な軟骨欠損補填デバイス/再生スキャフォールドとなる可能性が示唆された。この材料は魚類由来であり病原伝搬性の観点からも優れる可能性がある。軟骨疾患は高齢化社会における寝たきりの重大な原因の一つであり、その治療に貢献することは、公衆衛生の面でも、医療経済面でも高い意義が期待される。
|
