Study on cortical porosity in Japanese women: cross-sectional analysis by HR-pQCT

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagasaki University
• Principal Investigator: CHIBA Ko 長崎大学, 医歯薬学総合研究科(医学系), 助教 (00457574)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 皮質骨多孔性

Outline of Final Research Achievements

Bone microstructural analysis by high-resolution CT (HR-pQCT) was performed on 140 Japanese women over the age of 50, and the factors involved with cortical bone porosity were analyzed.
Cortical porosity occurred more frequently in cases where trabecular bone was preserved in this study.
This result is a new finding in the research of osteoporosis and may become a basis for proposing a new hypothesis on the mechanism on bone deterioration.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

皮質骨多孔性は、通常の臨床用画像装置では検出することができないが、骨脆弱性を引き起こす骨構造の重要な因子である。
本研究で、皮質骨多孔性の発生メカニズムの糸口が見つかり、かつ、今後さらに、皮質骨多孔性と、日常診療で知り得る患者情報との関与を探索することで、骨折リスク評価や骨折予防へ貢献できると考えられる。