Development of precision medicine for the therapy to metastatic prostate cancer using genome-eide SNP array

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kyushu University
• Principal Investigator: Shiota Masaki 九州大学, 大学病院, 講師 (20635445)
• Co-Investigator(Kenkyū-buntansha): 江藤 正俊 九州大学, 医学研究院, 教授 (90315078)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 転移性前立腺癌 / 一塩基多型 / 個別化医療

Outline of Final Research Achievements

Hormone therapy is widely used for prostate cancer. However, the effect varies greatly among individuals. Therefore, in order to clarify the genetic background among individuals related to the therapeutic effect of hormone therapy, we investigated the relationship between gene polymorphism and the effect of hormone therapy. As a result, it was revealed that polymorphisms of some genes related to androgen metabolism are associated with therapeutic effect.

Free Research Field

泌尿器腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、ホルモン療法中のアンドロゲン代謝の個人差がホルモン療法の治療効果に影響していることが示された。また、今後のゲノムワイド解析の結果を含めて、遺伝子多型がホルモン療法の個別化治療に応用できる可能性が示唆された。