2020 Fiscal Year Final Research Report

Development of non-coding RNA-targeting therapy for refractory renal carcinoma

Research Project

Project/Area Number	17K11166
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Urology
Research Institution	Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Principal Investigator	Kawamura Sadafumi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (40292213)
Co-Investigator(Kenkyū-buntansha)	佐藤賢一地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055) 玉井恵一地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
Project Period (FY)	2017-04-01 – 2021-03-31
Keywords	non coding RNA
Outline of Final Research Achievements	Renal carcinoma is the third most common malignancy following prostate and bladder cancer, while the mortality is the highest (40%) among them. We identified non coding RNA HOTAIR which is involved in the malignant characteristics. We further identified a novel non-coding RNA which is also promote cancer malignancy.
Free Research Field	腫瘍学
Academic Significance and Societal Importance of the Research Achievements	私たちはnon-coding RNAに着目して、癌の悪性度を亢進させる新たなnon-coding RNAを同定した。詳細な分子機構の解析を行うことで、将来的に治療標的となる可能性がある。