Elucidation of cervical cancer microenvirnment - aiming to supress cancer cell behavir affected by stromal cells

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Takuya Murata 川崎医科大学, 医学部, 准教授 (20714207)
• Co-Investigator(Kenkyū-buntansha): 中村 隆文 川崎医科大学, 医学部, 教授 (20303969) ; 下屋 浩一郎 川崎医科大学, 医学部, 教授 (40291950)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 転移 / がん関連線維芽細胞 / 子宮頸がん

Outline of Final Research Achievements

Trans membrane protein TM4SF1 and protein X was upregulated in cervical cancer-associated fibroblast (CAF) that had ability to induce cervical cancer cell line ME180 metastasize to the lymph node in nude mouse xenograft model. We screened Chb-PIP library and Chb-PIP-T strongly inhibited transcription of both TM4SF1 and protein X genes. We found that Chb-PIP-T inhibited the lymph node metastasis of ME180 in nude mouse co-transplantation xenograft model with statistical significance (p=0.020).

Free Research Field

婦人科がん

Academic Significance and Societal Importance of the Research Achievements

転移抑制剤が開発されれば、子宮頸がんの予後が著しく改善され、子宮頸がんの進行や再発に苦しむ患者さんにとって大きな福音となる。