Physiological evaluation on the function of stria vascularis in the inner ear based on the difference of intracorporeal estrogen concentration.

2022 Fiscal Year Final Research Report

• Project/Area Number: 17K11345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Inui Takaki 大阪医科薬科大学, 医学部, 講師 (60465614)
• Co-Investigator(Kenkyū-buntansha): 森 禎章 関西福祉科学大学, 保健医療学部, 名誉教授 (70268192)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Keywords: 加齢性難聴 / 女性ホルモン / 卵巣摘出動物モデル / 蝸牛内直流電位 / 蝸牛血流

Outline of Final Research Achievements

It is known that the amount of estrogen in the body has effects on hearing condition such as the sex difference of hearing level of presbycusis. As the metabolism of calcium in the cochlear seems important to the hearing condition, at the present study, we evaluated effects of the intracellular ionic transportation pathways in cochlear by physiological methods. In conclusion, we found that the intracellular metabolism of calcium mediated by calmodulin plays an important role in the generation and preservation of endocochlear potentials.

Free Research Field

内耳聴覚、平衡覚

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果はまだ限定的であるが、これをさらに発展させていくことで、高齢女性の加齢性難聴へのあらたな治療および予防介入に繋がる可能性がある。これによりQOLが改善すれば、活動的な女性高齢者の社会参画に繋げることができ、結果として社会的にも大きな意義を持つ可能性がある。