2022 Fiscal Year Final Research Report
New therapeutic strategies using a micro RNA in the stromal cell-derived exosomes
| Project/Area Number |
17K11522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Showa University (2019-2022)
Jikei University School of Medicine (2017-2018) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Keywords | 神経芽腫 / microRNA |
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| Outline of Final Research Achievements |
A new treatment is necessary to dramatically improve the outcome of advanced neuroblastoma. The microRNAs research has expressed in many other malignant tumors in recent years. Therefore, in this study, we have been conducting research with the aim of using microRNAs, which are deeply involved in the metastasis and proliferation of neuroblastoma, as new treatments. In the first research year, we have extracted microRNAs that are specifically expressed in human neuroblastoma cell lines and fetus in rat and mouse. After that, due to the COVID-19 and the relocation of the researcher's affiliated facility, the planned research was significantly delayed, and satisfactory research results were not obtained.
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| Free Research Field |
小児外科学
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| Academic Significance and Societal Importance of the Research Achievements |
進行神経芽腫の治療成績を飛躍的に向上させるための新たな治療法として、神経芽腫の転移・増殖に深く関与するmicroRNAを担癌状態の個体へ投与する治療法が有効であるかを検討することが本研究の目標であった。残念ながら、諸般の事情で本治療法の可能性を示唆する有効な情報を得ることができなかったが、学術的意義は高く、今後も継続して研究を続けていきたい。
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