The effect of chemical chaperones in the post-cardiac arrest syndrome model

2022 Fiscal Year Final Research Report

• Project/Area Number: 17K11568
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kanazawa University
• Principal Investigator: Okajima Masaki 金沢大学, 医学系, 教授 (00361999)
• Co-Investigator(Kenkyū-buntansha): 谷口 巧 金沢大学, 医学系, 教授 (30301196)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Keywords: 心肺停止 / ケミカルシャペロン / 小胞体ストレス応答 / フェニル酪酸

Outline of Final Research Achievements

Post-cardiac arrest syndrome is considered to be one of the pathologies caused by ischemia-reperfusion injury. Endoplasmic reticulum stress response plays a significant role in this condition, and chemical chaperones have shown effectiveness. The plan was to investigate whether the chaperone 4-PBA could alleviate brain and myocardial injury in a rat asphyxiation model. The study utilized mice that achieved spontaneous cardiac recovery within 3 minutes after confirming cardiac arrest by discontinuing artificial respiration and initiating cardiopulmonary resuscitation. To ensure the survival and quality of the mice, it was crucial to maintain consistency in the chest compression technique, and therefore attempts were made to establish a stable cardiopulmonary arrest and resuscitation model.

Free Research Field

救急医学

Academic Significance and Societal Importance of the Research Achievements

心肺蘇生の普及などにより、心肺停止患者の生存率や社会復帰率は増加傾向にあるが、いまだ十分とは言えない。その原因は心停止後症候群にあり、なかでも心停止後脳障害、心停止後心筋障害が生命予後および神経学的予後を左右する病態である。この虚血再灌流障害を本態とする心停止後症候群には小胞体ストレス応答が大きく関与しており、これをケミカルシャペロンにてコントロールすれば、心停止後脳障害や心筋障害が軽減し、大きな社会貢献につながる。