Elucidation of the pre-metastasis niche formation mechanism of oral cancer by TANGO

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K11621
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nara Medical University
• Principal Investigator: Sasahira Tomoonori 奈良県立医科大学, 医学部, 講師 (90405374)
• Co-Investigator(Kenkyū-buntansha): 栗原 都 奈良県立医科大学, 医学部附属病院, 研究員 (40453170)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 口腔癌 / TANGO

Outline of Final Research Achievements

TANGO acts tumor-promotingly in oral cancer. We have conducted detailed studies on the functions and signal pathways of TANGO in oral cancer using clinical specimen and oral cancer cell line. As a result, NCAPH, mast cell chymase, SRPX2, PXDN, MUC20, etc. were newly identified as new molecules related to TANGO. Among these, DHRS9 acts on tumor inhibitory properties in oral cancer, but other molecules act as oncgene in oral cancer. It was also revealed that some of them are detected as secretory proteins not only in tumors but also in serum. It is expected that it may be a molecular marker in oral cancer

Free Research Field

口腔病理学

Academic Significance and Societal Importance of the Research Achievements

新たに見いだされた因子の多くは口腔癌において腫瘍促進的に作用することより、それらを標的とした分子治療の可能性が期待される。また血中において検出可能な分泌タンパクもいくつか含まれていたことより、検査マーカーとしての応用も考えられる。特に唾液中からも検出されることが明らかになれば、簡便かつ低侵襲な腫瘍マーカー検査が可能になり、ひいては口腔癌の早期発見・治療による予後向上に寄与できるものと期待される。