2022 Fiscal Year Final Research Report
The effects of antimicrobial treatment on biofilm activity and component using caries and periodontitis biofilm model
| Project/Area Number |
17K11721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
向井 義晴 神奈川歯科大学, 歯学部, 教授 (40247317)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Keywords | biofilm / polymicrobial / dentin / demineralization / remineralization / root caries / next generation sequence / TMR |
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| Outline of Final Research Achievements |
Using ex vivo plymicrobial biofilms, We studied effects od novel toothpastes and mouthwashes on oral biofilms for the purpose of treatment and prevention of root caries. S-PRG filler releases ions such as fluoride, strontium and borate ion, which inhibits demineralization of dentine and exerts antibacterial effects. S-PRG filler-containing toothpastes and mouthwashes were found to be effective against biofilm bacterial count and activity (Am J Dent 2019;32:245-250, Am J Dent 2023;36:91-94). In addition, our results as for analysis of bacterial community in polymicrobial biofilms which was grown simulating root caries would be helpful for elucidation of root caries pathogenic mechanism（Am J Dent 2020;33:55-58）.
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| Free Research Field |
保存修復学
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| Academic Significance and Societal Importance of the Research Achievements |
日本人の高齢化が進み、歯科分野での様々な対策が実を結び、残存歯は増加したが、一方で、根面齲蝕の発症が増加している。歯周病に罹患した場合、高確率で根面齲蝕が発症することも指摘されており、歯科分野での高齢化社会対策として、重要な課題となっている。歯冠部齲蝕とは異なるバイオフィルム細菌叢の問題や、エナメル質と根面象牙質の臨界pHの違い、加えて脱灰メカニズムの違い（象牙質はミネラルの溶出に加えてコラーゲンの分解が生じる）にも関係の深いことが指摘されており、歯質側とバイオフィルム側から分析した、様々な報告はされてはいるものの、理論的かつ有効な歯根面象牙質齲蝕の治療法および予防法の開発には至っていない。
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