Development of layered bio-degradable PLGA membranes

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11778
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Sasaki Jun-Ichi 大阪大学, 歯学研究科, 講師 (50530490)
• Co-Investigator(Kenkyū-buntansha): 今里 聡 大阪大学, 歯学研究科, 教授 (80243244)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 歯科材料学 / 生体材料学 / 歯周組織再生療法 / 歯科用メンブレン / PLGA

Outline of Final Research Achievements

The objective of this study was to evaluate the physicochemical and biological characteristics of bilayer biodegradable PLGA membrane, and to assess whether the bilayer PLGA membrane could be used for periodontal tissue regeneration. Physicochemical analyses revealed that bilayer membranes possessed appropriate mechanical properties for clinical use and excellent barrier effects to seal bone defects. It was also confirmed that porous layer of the membrane promoted proliferation and osteogenic differentiation of mesenchymal stem cells, thus resulting in bone regeneration in vivo. The present study demonstrates that the bilayer biodegradable PLGA membranes fabricated facilitate tissue regeneration in vivo, and therefore represent a prospective biomaterial for GTR therapy.

Free Research Field

生体材料学

Academic Significance and Societal Importance of the Research Achievements

現在、歯科で使用されている生体吸収性メンブレンには、動物由来材料を用いたものとPLGAを基材としたものがあるが、いずれも細胞の接着や増殖、分化等の挙動を制御する能力は備えていない。一方、本研究で開発に成功した二層性PLGAメンブレンは、組織再生を担う細胞の挙動制御を可能にする新規の生体吸収性材料であり、次世代の歯周組織再生技術の発展に貢献できると考えられるため、大きな社会的意義をもつ。