Analysis of the molecular mechanisms on the development of highly malignant oral squamous cell carcinoma derived from bone marrow stem cells and its clinical significance

2021 Fiscal Year Annual Research Report

• Project/Area Number: 17K11887
• Research Institution: Dokkyo Medical University
• Principal Investigator: 川又 均 獨協医科大学, 医学部, 教授 (70224847)
• Co-Investigator(Kenkyū-buntansha): 内田 大亮 愛媛大学, 医学系研究科, 教授 (20335798)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: 口腔扁平上皮癌 / 発生母細胞 / 唾液腺 / 骨髄細胞

Outline of Annual Research Achievements

昨年度に引き続き，口腔扁平上皮癌組織を採取した際にはRNAを抽出し，全遺伝子発現をマイクロアレイにて検索し，上皮幹細胞由来か，唾液腺幹細胞由来か，骨髄由来かを検討しながら治療戦略を立てている．それと同時に，使用していくマイクロアレイチップで全遺伝子発現を検索し，詳細な臨床データをデータベース化していき，骨髄由来超高悪性度口腔扁平上皮癌を簡便に識別できる数個のマーカーの検索を進めている．
これまでの研究を基に多くの論文が発表でき，現在，それらの原著論文をまとめる形で，記述的総説論文を執筆している．

Research Products

• [Journal Article] Molecular and histopathological analysis of peripheral ameloblastoma of the mandible mimicking a papillomatous lesion on the buccal mucosa (2022)
  • Author(s): Sayaka Izumi，Yuske Komiyama，Michiko Shimura，Yuta Sawatani，Ryo Oshima，Mamabu Zama，Chonji Fukumoto，Ryouta Kamimura，Erika Yaguchi，Takahiro Wakui，Koh-ichi Nakashiro，Daisuke Uchida，Hitoshi Kawamata
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: - Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry (2021)
  • Author(s): Ryouta Kamimura，Daisuke Uchida，Shin-ichiro Kanno，Ryo Shiraishi，Toshiki Hyodo，Yuta Sawatani， Michiko Shimura，Tomonori Hasegawa，Maki Tsubura-Okubo，Erika Yaguchi，Yuske Komiyama，Chonji Fukumoto，Sayaka Izumi，Atsushi Fujita，Takahiro Wakui，Hitoshi Kawamata
  • Journal Title: International Journal of Molecular Science Volume: 22 Pages: -
  • DOI: 10.3390/ijms222010913.
  • Peer Reviewed / Open Access
• [Journal Article] Oral squamous cell carcinoma may originate from bone marrow-derived stem cells. (2021)
  • Author(s): Hasegawa T, Nakashiro KI, Fukumoto C, Hyodo T, Sawatani Y, Shimura M, Kamimura R, Kuribayashi N, Fujita A, Uchida D, Kawamata H.
  • Journal Title: Oncol Lett Volume: 21 Pages: -
  • DOI: 10.3892/ol.2021.12431
  • Peer Reviewed / Open Access
• [Journal Article] Morphometric and histomorphometric evaluations of High-Purity Macro/Microporous β-TCP in maxillary sinus floor elevation (2021)
  • Author(s): Atsushi Fujita, Chonji Fukumoto, Tomonori Hasegawa, Yuta Sawatani, Hitoshi Kawamata
  • Journal Title: BMC Oral Health Volume: 21 Pages: -
  • DOI: 10.1186/s12903-021-01797-5.
  • Peer Reviewed / Open Access
• [Journal Article] Share Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients. (2021)
  • Author(s): Tsubura-Okubo M, Komiyama Y, Kamimura R, Sawatani Y, Arai H, Mitani K, Haruyama Y, Kobashi G, Ishihama H, Uchida D, Kawamata H.
  • Journal Title: Int J Oral Maxillofac Surg. Volume: 50 Pages: 906-914
  • DOI: 10.1016/j.ijom.2020.10.004
  • Peer Reviewed / Open Access
• [Journal Article] Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study (2021)
  • Author(s): Fukumoto C, Oshima R, Sawatani Y, Shiraishi R, Hyodo T, Kamimura R, Hasegawa T, Komiyama Y, Izumi S, Fujita A, Wakui T, Kawamata H
  • Journal Title: Cancers (Basel) Volume: 13 Pages: -
  • DOI: 10.3390/cancers13225843.
  • Peer Reviewed / Open Access
• [Journal Article] Share Effectiveness of cetuximab as preemptive postsurgical therapy for oral squamous cell carcinoma patients with major risk: a single-center retrospective cohort study. (2021)
  • Author(s): Fukumoto C, Sawatani Y, Shiraishi R, Zama M, Shimura M, Hasegawa T, Komiyama Y, Fujita A, Wakui T, Kawamata H.
  • Journal Title: Invest New Drugs Volume: 39 Pages: 846-852
  • DOI: 10.1007/s10637-021-01062-0
  • Peer Reviewed / Open Access