Facilitation of AMPA receptors trafficking in Pre-injury induces functional recovery after brain injury

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K13060
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Yokohama City University
• Principal Investigator: Nakajima Waki 横浜市立大学, 医学研究科, 特任助教 (10737323)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 機能回復 / リハビリテーション / AMPA受容体 / 予防

Outline of Final Research Achievements

This study revealed that mice reared enrich environment improve the learning efficiency of the reaching task. In addition, mice reared enrich environment tend to induce functional recovery in early phase of brain injury. In this study, although the mechanism of this phenomenon could not be proved, living in enrich environment before brain injury might recovery after brain injury and reduce social losses.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

脳に損傷を受ける前に豊かな環境で生活する（主に運動を定期的に行う）ことで、脳損傷後の回復が早く、社会的負担が軽減する可能性があると考えられる。これらの結果をそのまま日常生活に応用することは検討が必要であるが、介護予防の観点からも有用な知見と考えられる。