Neural substrates for the functional shift of neural circuit during learning

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K13114
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental mechanisms and the body works
• Research Institution: Fukushima Medical University
• Principal Investigator: Setogawa Susumu 福島県立医科大学, 医学部, 博士研究員 (30760508)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 学習 / 習慣形成 / 手続き記憶 / 大脳基底核

Outline of Final Research Achievements

To reveal the neural mechanisms underlying the habit formation, we performed behavioral, pharmacological, and small-animal neuroimaging analysis using rats. This study suggests that the dorsal striatum and cerebellum contribute to the habitual learning and outputs of learned behavior respectively.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

習慣形成に関わる神経基盤の破綻は、薬物依存症など様々な疾患と関与することが分かっている。そのため、本研究成果は依存症等の精神疾患に対する新たな治療法の開発や発症メカニズムの解明に向けて基礎的知見を提供しうるものと期待できる。