The mechanisms of exercise-induced glucose utilization by hexokinase and mitochodria in skeletal muscle

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K13196
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: Masuda Hiroyuki 新潟医療福祉大学, 健康科学部, 助教 (10738561)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 運動 / 骨格筋 / ミトコンドリア / ヘキソキナーゼ / Akt

Outline of Final Research Achievements

Accumulating evidence reveals that exercise stimulates glucose transport in skeletal muscle. Hexokinase phosphorylates glucose to regulate glucose metabolism. Akt is activated by exercise. In heart muscle, Akt-mediated phosphorylation of hexokinase increases mitochondrial association. This association, which include translocates to mitochondria and increases mitochondrial hexokinase binding, contributes to generate ATP. We hypothesized that Akt-mediated phosphorylation of hexokinase increases during exercise. Contrary to our hypothesis, exercise did not change mitochondrial hexokinase binding.

Free Research Field

分子運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまでGLUT4による血糖取り込み過程に偏重していた骨格筋糖代謝研究において、ミトコンドリアでの血糖利用を調節するという新たな視点から、この研究分野を再構築することを目指した。本研究の成果は、身体活動による糖代謝機能の包括的な解明への一助となることが期待される。