2018 Fiscal Year Final Research Report
Analysis of clonal expansions in gastritis tissues
| Project/Area Number |
17K14990
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Echizen Kanae 金沢大学, がん進展制御研究所, 特任助教 (20743834)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | 胃炎 / クローン拡大 |
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| Outline of Final Research Achievements |
Epithelial cells which have strong genetic alterations are largely expanded in cancer tissues. To analyze clonal expansion in pre-cancerous gastritis tissues, we did exome sequence analyses with gastritis tissues adjacent to stomach cancer. We analyzed 19 gastritis tissues from 4 herlicobacter pylori infected patients.
From these DNA sequence analyses, we found that epithelial cells which have some mutations are already expanded in gastritis tissues. But these are smaller than clonal expansions in cancer tissues. These results suggest that clonal expansions have started from pre-cancerous areas.
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| Free Research Field |
腫瘍遺伝学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、胃がんの前がん病変である胃炎組織において、すでに遺伝子変異を持った上皮細胞のクローン拡大が進行していることが明らかとなった。胃炎領域におけるクローン拡大の状況や、その発がんとのかかわりは未解明であり、本研究によって、ピロリ菌感染による胃炎の新たな病態が明らかとなった。本研究によって解明した胃の前がん病変における病態は、今後の発がん予防・発がんメカニズムの解明に繋がると考えられる。
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