Novel immune organs producing innate lymphoid cells - function and abnormality of mediastinal fat-associated lymphoid clusters -

2019 Fiscal Year Annual Research Report

• Project/Area Number: 17K15388
• Research Institution: Hokkaido University
• Principal Investigator: エレワ ヤセル 北海道大学, 獣医学研究院, 助教 (30782221)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: reprotoxicity / Lung injury / Respiratorty diseases / lung cancer / MFALCs / Mycoplasma pulmonis

Outline of Annual Research Achievements

During FY2019, I could reveal the Roles of royal jelly and cod liver oil in ameliorating the Food Yellow4 reprotoxicity in rat testes.Icould publish these data in one high impact Journal with the title of: Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil (Elewa et al. 2019, Ecotoxicol Environ Saf). Additionally, we have collaboration with two laboratories within Hokkaido University (Laboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Medicine; and Laboratory of Innovative Nanomedicine, Faculty of Pharmaceutical Sciences) to reveal the role of MFALCs in the susceptibility to Mycoplasma pulmonis (Boonyarattanasoonthorna et al. 2019, INFECTION GENETICS AND EVOLUTION) as well as the use of the nanoparticles as innovative therapeutic approach for metastatic lung cancer, we could publish our data in one of the top 10% impacted Journal (Abd Elwakil et al. 2019, ADVANCED FUNCTIONAL MATERIALS).Also, during the FY2019,I collaborated with other researchers within my lab and other several institutions within Japan and outside Japan and we could publish another11 papers from this collaborative work.

Research Products

• [Journal Article] Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil. (2019)
  • Author(s): Elewa, Y. H. A., Mohamed, A.A., Galal, A.A.A., El-Naseery, N.I., Ichii, O., Kon, Y.
  • Journal Title: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Volume: 169 Pages: 696-706
  • DOI: 10.1016/j.ecoenv.2018.11.082
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lung-Endothelium-Targeted Nanoparticles Based on a pH-Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer. (2019)
  • Author(s): Abd Elwakil M.M., Khalil I.A., Elewa, Y. H. A., Sato Y., Shobaki N., Kon Y. , Harashima H.
  • Journal Title: ADVANCED FUNCTIONAL MATERIALS. Volume: 29 Pages: 1807677
  • DOI: 10.1002/adfm.201807677
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice. (2019)
  • Author(s): Boonyarattanasoonthorna,T., Elewa, Y. H. A., Tag-El-Din-Hassan,H. T., Morimatsua, M., Agui, T.
  • Journal Title: INFECTION GENETICS AND EVOLUTION Volume: 73 Pages: 55-65
  • DOI: 10.1016/j.meegid.2019.04.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Possible role of the novel mediastinal fat associated lymphoid clusters in human, animals and poultry respiratory diseases progression. (2019)
  • Author(s): Y. H. A. Elewa, O. Ichii, S., T. Nakamura, Y. Kon.
  • Organizer: The 4th international scientific Veterinary Medicine Conference” Veterinary Medicine: locomotive for development”. Hurghada, Egypt.
  • Invited
• [Presentation] Keynote speaker. “Elucidation of the pathogenesis of lung asthma development and recovery: Possible immune cells’ crosstalk within lung and mediastinal fat associated lymphoid clusters in papain induced lung asthma mice model. (2019)
  • Author(s): Y. H. A. Elewa, O. Ichii, S., T. Nakamura, Y. Kon.
  • Organizer: The 7th Congress of Asian Association of Veterinary Anatomists (Asian AVA), Jeju, Korea.
  • Int'l Joint Research
• [Presentation] “Possible role of natural helper cells within the mediastinal fat-associated lymphoid cluster and lung in papain induced lung asthma mouse model”. (2019)
  • Author(s): Y. H. A. Elewa, O. Ichii, T. Nakamura, Y. Kon.
  • Organizer: The 65th annual meeting of the Japanese the Anatomical Society. Rakuno Gakuen University, Japan.
  • Int'l Joint Research