2018 Fiscal Year Final Research Report
Sugar traffic in invertebrate endocrine organ
| Project/Area Number |
17K15398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Insect science
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | トレハロース / トランスポーター |
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| Outline of Final Research Achievements |
Interruption of sugar port from hemolymph to corpora allata leads to death in insects. However, the sugar transport remains unknown. Trehalose is a disaccharide sugar as an energy source, which is contained in the hemolymph. The hydrolysis of trehalose is underwent by trehalase, TREH2 in peripheral tissues. This study revealed that the topology of membrane-bound TREH2 in Bombyx mori by using Immunohistochemistry. The study also showed that a novel trehalose transporter TRET2 using the Xenopus oocyte expression system.
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| Free Research Field |
昆虫分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
糖は生物の代謝で重要である．昆虫もヒトと同様に，糖を利用して生きている．生存に不可欠な器官に糖の供給が停止すれば，昆虫は死に至る．本研究では，チョウ目昆虫における糖の輸送を明らかにした．この輸送を阻害する働きを示す薬剤が見つかれば，新規の農薬の作用点となる可能性が高い．
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