• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2019 Fiscal Year Final Research Report

Investigation and development of terpenoids as the cancer prevention agents

Research Project

  • PDF
Project/Area Number 17K15473
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Natural medicines
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

Matsumoto Takahiro  京都薬科大学, 薬学部, 助教 (30780431)

Project Period (FY) 2017-04-01 – 2020-03-31
Keywordsがん予防 / Citrus limon / Lansium domesticum / Petasites japonicus / 抗変異原性 / がん幹細胞
Outline of Final Research Achievements

To investigate the cancer prevention potency of natural products derived from plant materials, we isolated 41 compounds, including 17 new compounds from the peels of Citrus limon, and Lansium domesticum. The chemical structures of the isolated compounds were elucidated by chemical/physicochemical evidence, and nuclear magnetic resonance spectroscopy and mass spectrometry results. The antimutagenic effects of the isolated and structure-elucidated compounds against heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were evaluated by the Ames test and in vivo micronucleus test. As a result, oral intake of limonin and lansionic acid significantly decreased the frequency of micronucleated reticulocytes treated with PhIP administration.
In addition, we isolated the compounds have cytotoxic activities against both U-251 MG cells and their CSCs from the aerial parts of Petasites japonicus.

Free Research Field

天然資源系薬学

Academic Significance and Societal Importance of the Research Achievements

Limonin および lansionic acid が発がんを抑えられるという知見が得られた.これらの化合物は食品として用いられているレモン (Citrus limon) および Lansium domesticum の果皮に主要成分として含まれていることから,エビデンスに基づいた,がん予防に有効な新規機能性食品を提案することができた.抗がん剤抵抗性を持つ CSC の駆逐に有効と考えられる化合物については,継続して有効性を証明することで,がん再発予防薬の開発につながる可能性がある.また,本研究では,今後医薬品シーズの開拓研究を進める上で有用な化合物ライブラリーの構築に成功した.

URL: 

Published: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi