2019 Fiscal Year Final Research Report
Usefulness of Pharmacogenomics in Clinical Practice
| Project/Area Number |
17K15504
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Hira Daiki 立命館大学, 薬学部, 助教 (50636959)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 個別医療 / 遺伝子多型解析 / 医療薬学 |
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| Outline of Final Research Achievements |
In this study, the impact of the CYP2D6 polymorphism on the effect of Tramadol was evaluated to explain the individual difference in analgesic.
There are few genetic variants in which the activity of CYP2D6 is extremely decreased in Japanese people. However, even genetic polymorphisms in which the activity of CYP2D6 is slightly decreased, which, which are frequently observed in Japanese, significantly affect the efficacy of Tramadol.
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| Free Research Field |
臨床薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、薬物の効果の個人差を遺伝子変異の有無により説明することを目的としている。遺伝子変異の評価に基づいて個々の患者さんに合わせた薬剤選択や投与量決定が可能となれば、(1) いち早く最適な治療効果が達成できることによる治療効率の向上や、(2) 過剰投与が防止できることによる副作用頻度の低下という医学的なメリットに加え、(3) 投与量の最適化による薬剤費の負担軽減や、(4) 副作用頻度の低減による副作用の治療のための医療費の軽減など、経済学的なメリットが期待できる。
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