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2019 Fiscal Year Final Research Report

Characterization of diffuse-type gastric cancer with CLDN18 fusion and drug discovery for it

Research Project

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Project/Area Number 17K15636
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

Tanaka Atsushi  東京大学, 医学部附属病院, 助教 (80779687)

Project Period (FY) 2017-04-01 – 2020-03-31
Keywordsびまん型胃癌 / CLDN18転座 / RHOA変異
Outline of Final Research Achievements

Using surigically resected gastric cancer, I uncovered that fusion-positive diffuse-gastric cancer (DGC) had high TNM stage and frequent metastasis compared with non-fusion DGC. In addition, fusion-positive DGC in young patient cohort showed aggresive phenotype, suggesting they might need more intensive treatment such as chemotherapy. Furthermore, I found many genes, pathways and potential therapeutic targets that are enriched in fusion-positive DGC.

Free Research Field

消化器癌及び肉腫

Academic Significance and Societal Importance of the Research Achievements

胃癌は組織学的に腸型とびまん型に大別される。びまん型胃癌は胃癌の40%程度を占め、進行の早い癌であり、5年生存率は20%弱と予後が悪い。しかし、HER2等の分子標的薬適応になる症例は少なく、分子標的薬を含めた新たな治療戦略が特に必要とされていた。近年びまん型にはRHOA変異、CLDN18転座が多くみられることが判明したが、その臨床的意義や病態は不明であった。本研究で得られた成果はこれらの問題を解決する基盤になるものであり、学術的意義、社会的意義があると考える。

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Published: 2021-02-19  

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