2019 Fiscal Year Final Research Report
Development of a novel drug therapy for Bladder pain syndrome
| Project/Area Number |
17K15792
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Tohoku Medical and Pharmaceutical University (2018-2019)
Kansai University of Nursing and Health (2017) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 間質性膀胱炎 / 膀胱痛症候群 / 過活動膀胱 / リポポリサッカライド / ガバペンチン |
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| Outline of Final Research Achievements |
The etiology of Interstitial cystitis/bladder pain syndrome (IC/BPS) is still not completely understood, and effective drug treatments have not been established. Therefore, we created chronic cystitis model which causes long-lasting bladder pain and overactive bladder in rats. We further tested the effect of gabapentin on those symptoms in a rat model of chronic cystitis. Gabapentin showed analgesic effects for bladder pain, and prevented the increased frequency of the voiding observed in chronic cystitis model. The results of this study indicated that gabapentin is effective on both symptoms in this chronic cystitis model.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
膀胱痛や頻尿を主訴とする間質性膀胱炎は、膀胱痛症候群とも呼ばれる難治性疾患であるが、未だ有効な治療薬が確立されいないのが現状である。本研究は、間質性膀胱炎の病理・主症状を反映した慢性膀胱炎モデルを作製し、鎮痛補助薬として用いられているガバペンチンが膀胱痛だけでなく、頻尿症状も抑制することを見出した。すでに安全性が担保されている既存薬の再開発により、ガバペンチンを含むガバペンチノイドが間質性膀胱炎患者でみられる膀胱痛および過活動膀胱の両症状を改善する治療薬として期待できる。
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