2018 Fiscal Year Annual Research Report
Novel adjuvant method of malignant brain tumor neutron capture therapy with absorbed dose evaluation and tumor localization using composite boron and high-Z element nanoparticles.
| Project/Area Number |
17K15797
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ザボロノク アレクサンドル 筑波大学, 医学医療系, 助教 (20723117)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | BNCT / glioma / nanoparticles / boron / high-Z element |
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| Outline of Annual Research Achievements |
In the 2018 fiscal year, following stages of the main plan were accomplished. The synthesis of the composite nanoparticles was continued and boron nanoparticles were successful synthesized. As the stability of the compounds during high-Z element consolidation differed in the experiments, in vivo application was delayed. Animal tumor model using F98 rat glioma cells and Fisher rats was created. Accumulation of nanoparticles in animal tumor models was evaluated, though was below the expected values. The focus of experiments was shifted to drug delivery system including nanoparticle surface modifications and liposomal delivery of boron compounds. The results of the study were presented at several conferences and will be included in scientific publications.
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[Presentation] Hybrid gold and boron nanoparticles for treatment and boron dose estimation in boron neutron capture therapy for malignant glioma.2018
Author(s)
Zaboronok A, Taskaev S, Kanygin V, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Uspenskii S, Kaptakhanova P, Zelenetskii A, Selyanin M, Bekarevich R, Mitsuishi K, Sato E, Nakai K, Tsurubuchi T, Yoshida F, Ishikawa E, Mathis BJ, et al.
Organizer
The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
Int'l Joint Research
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[Presentation] Japan-Russia collaborative research on accelerator-based boron neutron capture therapy for malignant glioma.2018
Author(s)
Zaboronok A, KanyginV, Taskaev S, Bykov T, Kasatov D, Kolesnikov J, Koshkarev A, Makarov A, Shchudlo I, Volkova O, Mechetina L, Taranin A, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Zavjalov E, Akulov A, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
Organizer
The 6th Japan Russia Neurosurgical Symposium
Int'l Joint Research
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[Presentation] Boron neutron capture therapy for malignant brain tumors: current situation in the world, our experience in Russia and Japan, and further development perspectives.2018
Author(s)
Zaboronok A, Ishikawa E, Taskaev S, Bykov T, Kasatov D, Kolesnikov I, Koshkarev A, Makarov I, Shchudlo I, Volkova O, Mechetina L, Taranin A, Zavjalov E, Akulov A, Kanygin V, Kasatova A, Kichigin A, Byvaltsev V, Sato E, Nakai K, Mathis BJ, Yamamoto T, Matsumura A
Organizer
The 2nd Congress of Neurosurgeons of Uzbekistan
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[Presentation] Accelerator-based boron neutron capture therapy for malignant glioma using composite boron-gold nanoparticles: preclinical evaluation.2018
Author(s)
Zaboronok A, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Zelenetskii A, Uspenskii S, Khaptakhanova P, Ishikawa E, Nakai K, Yamamoto T, Mathis BJ, Tsurubuchi T, Matsumura A.
Organizer
The 77th Annual Meeting of the Japan Neurosurgical Society
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[Presentation] Boron neutron capture therapy for malignant glioma: our experience, present status and future perspectives.2018
Author(s)
Zaboronok AA, Kanygin VV, Taskaev SYu, Volkova OYu, Mechetina LV, Taranin AV, Zavjalov EL, Akulov AE, Kasatova AI, Kichigin AI, Byvaltsev VA, Sato E, Nakai K, Ishikawa E, Mathis BJ, Yamamoto T, Matsumura A
Organizer
The II Siberian Neurosurgical Congress
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