2018 Fiscal Year Final Research Report
Novel adjuvant method of malignant brain tumor neutron capture therapy with absorbed dose evaluation and tumor localization using composite boron and high-Z element nanoparticles.
| Project/Area Number |
17K15797
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | glioma / nanoparticles / radiotherapy / radiodiagnosis / BNCT |
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| Outline of Final Research Achievements |
Boron nanoparticles were synthesized by cascade ultrasonic dispersion / destruction of microparticles. The efficacy of the accelerator-based neutron source was proven using human and animal cells lines. Boron-related absorbed dose calculation method was tested and the unique formula was developed. As drug delivery system was crucial for targeted boron compound development, liposomal delivery was compared to standard low-molecular boron compounds in animal experiments. Our method allows in situ absorbed dose calculation using combination of boron and a High-Z element activation in the accelerator-based boron neutron capture therapy. Future implementation of our boron dose estimation method might be realized through modification of scintigraphy or isotope scanning.
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| Free Research Field |
radiation oncology
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| Academic Significance and Societal Importance of the Research Achievements |
In Japan, cancer is one of major reasons for morbidity and mortality, and the number of patients with malignant tumors is increasing year after year. The development of new forms of boron agents will move forward BNCT research and its future clinical application to extend life of cacner patients.
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