Identification of non-invasive novel biomarkers predicting future asthma exacerbations in adults and early-onset wheeze in children

2019 Fiscal Year Annual Research Report

• Project/Area Number: 17K15843
• Research Institution: Hokkaido University
• Principal Investigator: Goudarzi Houman 北海道大学, 医学研究院, 助教 (40713607)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: Birth cohort / Urinary biomarkers / Allergies in children / Adult asthma cohort

Outline of Annual Research Achievements

In a large-scale prospective birth cohort, we investigated the association of early life allergic conditions (wheeze, rhinoconjunctivitis, and eczema) with overweight/obesity risk in children at age 7. Also, we assessed the association of 3 urinary inflammatory biomarkers including 8-hydroxy-2 deoxyguanosine (8-OHdG), hexanoyl-lysin (HEL), and 4-hydroxynonenal (4-HNE) with the risk of allergic diseases at age 7 (n=568) and 10 years (n=428). With a longitudinal analysis, we found the prevalence of rhinoconjunctivitis (3.3 to 21.2%) and eczema (11.3% to 22.4%) significantly increased from early life to age 10. The prevalence of wheeze peaked at 4 years of age (21.6%) with a consequent decline at age 7 (13.3%) and 10 (9.2%). Among children aged 10, 41.5% had at least of the allergic diseases, 46.0% had FeNO >20 parts per billion (p.p.b), and 38.5% had blood eosinophil number >300/µl. At age 10, 70.5% and 22.3% of children were sensitized to inhaled and food allergens, respectively. Wheeze at age 0-2, 4 and 7 years of age was significantly associated with the risk of overweight/obesity at age 7. In contrast, rhinoconjunctivitis and eczema did not show any significant associations with the risk of overweight/obesity at age 7. Among examined urinary biomarkers, HEL had higher levels among children with wheeze at age 7. Currently, I am examining the association of urinary biomarkers and the development of allergic diseases at age 10. Among adult asthma patients, we found the association of abdominal visceral fat with urinary HEL and HNE biomarkers (n=206).

Research Products

• [Int'l Joint Research] University of Antwerp/Toxicological Center(ベルギー)
  • Country Name: BELGIUM
  • Counterpart Institution: University of Antwerp/Toxicological Center
• [Int'l Joint Research] Center of Environmental Medicine/Kaohsiung Medical University, Taiwan/NIEHS(その他の国・地域)
  • Country Name: その他の国・地域
  • Counterpart Institution: Center of Environmental Medicine/Kaohsiung Medical University, Taiwan/NIEHS
• [Int'l Joint Research] Johns Hopkins University/School of Medicne(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Johns Hopkins University/School of Medicne
• [Journal Article] Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children (2020)
  • Author(s): Araki A, Ait Bamai Y, Bastiaensen M, Van den Eede N, Kawai T, Tsuboi T, Miyashita C, Itoh S, Goudarzi H, Konno S, Covaci A, Kishi R
  • Journal Title: Environmental Research Volume: 183 Pages: 109212
  • DOI: 10.1016/j.envres.2020.109212
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms (2019)
  • Author(s): Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
  • Journal Title: J Allergy Clin Immunol Pract. Volume: 7(4) Pages: 1222-1229
  • DOI: 10.1016/j.jaip.2018.11.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study (2019)
  • Author(s): Ait Bamai Y, Bastiaensen M, Araki A, Goudarzi H, Konno S, Ito S, Miyashita C, Yao Y, Covaci A, Kishi R
  • Journal Title: Environment International Volume: 131 Pages: 105003
  • DOI: 10.1016/j.envint.2019.105003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Childhood allergies and obesity relationship: Identification of non-invasive biomarkers. (2019)
  • Author(s): 1.Houman Goudarzi, Satoshi Konno, Atsuko Araki, Sachiko Ito, Yu Ait Bamai, Chihiro Miyashita, Reiko Kishi.
  • Organizer: European Respiratory Society International Congress, Madrid, Spain
  • Int'l Joint Research
• [Presentation] Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido study. (2019)
  • Author(s): 2.Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Takahiko Mitsui, Houman Goudarzi, Kazutoshi Cho, Kimihiko Moriya, Tamie Nakajima, Yusuke Iwasaki, Tsuguhide Hori, Junboku Kajiwara, Nobuo Shinohara, Reiko Kishi.
  • Organizer: Joint Meeting of Asian Chapters of International Society for Environmental Epidemiology and the International Society of Exposure Science (ISEE-ISES AC 2019), Daegu, Korea.
  • Int'l Joint Research
• [Presentation] Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children. (2019)
  • Author(s): 4.Goudarzi Houman、荒木敦子、伊藤 佐智子、アイツバマイゆふ、宮下ちひろ、木村孔一、今野 哲、岸 玲子.
  • Organizer: 第1回日本アレルギー学会北海道支部地方会.
• [Presentation] 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連 (Associations between urinary phosphorous frame retardant metabolites and urinary inflammation markers among school children). (2019)
  • Author(s): 5.アイツバマイ ゆふ、Bastiaensen Michiel、荒木 敦子、Goudarzi Houman 、今野哲、伊藤 佐智子、宮下 ちひろ、Covaci Adrian、岸 玲
  • Organizer: 第89回日本衛生学会学術総会. Nagoya, Japan.
  • Int'l Joint Research
• [Presentation] Differential impact of obesity indices on systemic and sputum inflammatory biomarkers among asthma patients. (2019)
  • Author(s): 7.Houman Goudarzi, Satoshi Konno, Hironi Makita, Hirokazu Kimura, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura.
  • Organizer: The 59th Annual Meeting of the Japanese Respiratory Society, Tokyo, Japan.
  • Int'l Joint Research
• [Funded Workshop] Scientific writing workshop (2019)
• [Funded Workshop] Human biomonitoring of emergent contaminants (workshop) (2019)