2019 Fiscal Year Final Research Report
Identification of non-invasive novel biomarkers predicting future asthma exacerbations in adults and early-onset wheeze in children
| Project/Area Number |
17K15843
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | Birth cohort / childhood allergies / Overweight and obesity / Biomarkers / Early life wheeze |
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| Outline of Final Research Achievements |
We assessed association of early life allergic diseases with overweight/obesity risk in children at age 7. Also, we assessed the association of 3 urinary biomarkers including 8-hydroxy-2 deoxyguanosine (8-OHdG), hexanoyl-lysin (HEL), and 4-hydroxynonenal (4-HNE) with the risk of allergic diseases at age 7 (n=568) and 10 years (n=428). We found the prevalence of rhinitis (3.3 to 21.2%) and eczema (11.3% to 22.4%) increased from early life to age 10. Prevalence of wheeze peaked at 4 years of age (21.6%) with a decline at age 7 (13.3%) and 10 (9.2%). Among children aged 10, 41.5% had at least of the allergic diseases, 46.0% had FeNO >20 p.p.b, and 38.5% had blood eosinophil number >300/µl. At age 10, 70.5% and 22.3% of children were sensitized to inhaled and food allergens, respectively. Wheeze, but not other allergies, at age 0-2, 4 and 7 years of age was associated with risk of overweight/obesity at age 7. Also, HEL had higher levels among children with wheeze at age 7.
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| Free Research Field |
Respiratory Medicine
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| Academic Significance and Societal Importance of the Research Achievements |
We found that early-life asthma may increase the risk of overweight/obesity. Thus, the prevention of overweight/obesity could be possible with early detection and treatment of asthma. We identified biomarkers associated with allergies and applicable as predictors of wheeze/asthma among children.
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