Randomized phase 2 study of the efficacy of morphine for dyspnea in patients with interstitial lung disease

2022 Fiscal Year Final Research Report

• Project/Area Number: 17K15909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: NHO Kinki Chuo Chest Medical Center(Clinical Research Center)
• Principal Investigator: Matsuda Yoshinobu 独立行政法人国立病院機構近畿中央呼吸器センター, 心療内科, 心療内科医長 (40505666)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Keywords: 間質性肺疾患 / 呼吸困難 / モルヒネ / 緩和ケア

Outline of Final Research Achievements

Patient enrollment began on June 13, 2019 and 36/50 patients were enrolled as of March 31, 2023.The study was presented at the Joint Meeting of Palliative, Supportive and Psycho-Oncology Care in August 2020 and was selected as the outstanding presentation. In addition, the protocol of this study was published in 2021 in BMJ Opne.

Free Research Field

緩和ケア

Academic Significance and Societal Importance of the Research Achievements

現時点では、目標登録数である50例に到達していないが、本試験が完遂し、間質性肺疾患の呼吸困難に対するモルヒネの有効性が示されれば、モルヒネ注射剤の臨床試験としては初の結果であり、学術的意義が大きい。また、本研究の出口戦略である、①緩和ケア教育モジュールへの反映、②診療ガイドラインへの収載、③社会保険診療報酬支払い基金への検討依頼を通じて間質性肺疾患の呼吸困難に対するモルヒネの使用が標準治療になれば、多くの呼吸困難患者のQOL向上に役立つ。