• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

The measurement of acetaldehyde in human esophageal and gastric tissue and the effect of L-cysteine for reducing the incidence of esophageal and gastric cancers

Research Project

  • PDF
Project/Area Number 17K15917
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

Hatta Waku  東北大学, 大学病院, 助教 (30706932)

Research Collaborator Okata Hideki  
Project Period (FY) 2017-04-01 – 2019-03-31
Keywordsアセトアルデヒド / L-システイン
Outline of Final Research Achievements

We enrolled 10 subjects with active acetaldehyde dehydrogenase-2*1/*1 genotype and 10 subjects with the inactive acetaldehyde dehydrogenase-2*1/*2 genotype. In this study using L-cysteine and placebo lozenges, saliva and blood were collected and esophageal and gastric tissue was obtained after drinking. Then, the acetaldehyde and ethanol concentrations were measured. The acetaldehyde concentration of the saliva was significantly lower in those taking L-cysteine than in those taking the placebo. Acetaldehyde in the esophageal tissue was detected only in those taking L-cysteine lozenges.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

これまでにヒト生体内での食道組織からアセトアルデヒドを検出した報告はなく、本研究にてヒト生体内食道組織のアセトアルデヒドが初めて検出されたことは意義深い。L-システイン製剤投与例のみでアセトアルデヒドが検出されたことは意義深い結果である。これらより、食道組織へのアセトアルデヒドの曝露の経路として、これまでに最も有力と考えられてきた唾液の直接曝露とは異なる経路が存在する可能性が考えられた。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi