2019 Fiscal Year Final Research Report
Novel therapeutic approach using drug-loaded adipose-derived stem cells for colon cancer
| Project/Area Number |
17K15976
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 脂肪組織由来幹細胞 |
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| Outline of Final Research Achievements |
Systemic chemotherapy for cancer is prone to serious side effects. Adipose tissue-derived stem cells accumulate in cancer tissue and suppress the growth of cancer cells. Therefore, we attempted to develop a new treatment method by attaching particles that slowly release an anticancer drug to adipose tissue-derived stem cells, which exerts an effect only on the cancer tissue and has few side effects. As a result, although the cancer suppressive effect was confirmed, many problems were found in the effectiveness of the drug delivery system.
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| Free Research Field |
消化器疾患
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| Academic Significance and Societal Importance of the Research Achievements |
癌に対する化学療法は急速に発展しているが、全身化学療法は重篤な副作用が出やすいことが大きな課題である。本研究が目指したのは、腫瘍選択的に薬剤を到達させるdrug delivery systemとして脂肪組織由来幹細胞を用いることであり、病変部位選択的な治療効果により、副作用が少なく有効性の高い治療法を検討した。結果として、癌の抑制効果は認めたが、drug delivery systemとしては十分とは言えなかった。
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