Analysis of coronary blood flow using fluid dynamics and experimental method

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K16009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Ehime University
• Principal Investigator: Seike Fumiyasu 愛媛大学, 医学部附属病院, 助教 (10771561)
• Project Period (FY): 2021-03-01 – 2022-03-31
• Keywords: FFR / 流体力学 / IVUS / OCT / 心筋虚血

Outline of Final Research Achievements

The usefulness of fractional flow ratio (FFR) in determining treatment strategy for ischemic heart disease has been established. However, there have been few reports, both in Japan and overseas, on the calculation of FFR using anatomical information of coronary arteries obtained by intracoronary imaging devices (intravascular ultrasonography: IVUS and optical coherence tomography: OCT). Therefore, the applicant has already created a new algorithm to estimate FFR based on fluid dynamics theory using anatomical information. In this application, (1) FFR analysis with anatomical information using the algorithm and (2) analysis of blood flow using computational fluid dynamics software were studied.

Free Research Field

虚血性心疾患

Academic Significance and Societal Importance of the Research Achievements

本邦では高齢化、食の欧米化により虚血性心疾患の患者は年々増加してきている。流体力学の理論を用いることにより、心筋梗塞の発症予測、また必ずしも必要のない手術を回避することが可能となりうる、本研究が今後本邦及び今後の虚血性心疾患の治療に与える影響は大きいものと考えられる。