Relationship between inflammatory monocyte and atherosclerosis

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K16021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Kashiwagi Manabu 和歌山県立医科大学, 医学部, 助教 (70453181)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 単球サブセット / 急性心筋梗塞

Outline of Final Research Achievements

Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets: CD14+CD16－ monocytes and CD14+CD16+ monocytes, called as “inflammatory” and “pro-inflammatory”. We proved that increasing of pro-inflammatory monocyte could predict future coronary artery event. In patients with acute myocardial infarction, both inflammatory monocyte and interleukin-34 increased and related with each other. In addition, those increasing were associated with myocardial remodeling and major adverse cardiovascular events.

Free Research Field

冠動脈疾患

Academic Significance and Societal Importance of the Research Achievements

ヒト末梢血単球サブセットの評価が、冠動脈疾患患者におけるリスク層別化に寄与することが示唆された。また炎症性単球とインターロイキン34の上昇は急性心筋梗塞後の心筋救済への関与も示唆されるため、さらなる機序検討により心筋壊死後に対する新規治療の礎となると考えられた。