The strategy for targeting Sp1 to eludicate CML cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16193
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: Koyama Daisuke 自治医科大学, 医学部, 客員研究員 (50741071)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 慢性骨髄性白血病 / Sp1 / オートファジー

Outline of Final Research Achievements

Chronic myeloid leukemia is a myeloproliferative neoplasm that driven by BCR-ABL tyrosine kinase. BCR-ABL is degraded by autophagy. It was clarified that Sp1 plays the crucial role for the expression of autophagy-related genes.

Free Research Field

血液学

Academic Significance and Societal Importance of the Research Achievements

慢性骨髄性白血病を根治するための新規治療戦略を開発するための理論的基盤となる。