2020 Fiscal Year Research-status Report
Effectiveness of early introduction of ten-valent pneumococcal conjugate vaccine (PCV-10) on reducing pneumococcal bacterial load in the nasopharynx among neonates.
| Project/Area Number |
17K16272
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| Research Institution | Nagasaki University |
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Principal Investigator |
ドバデル ビム 長崎大学, 熱帯医学・グローバルヘルス研究科, 助教 (80761113)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Keywords | pneumococcus / serotypes / PCV10 / children / pneumonia |
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| Outline of Annual Research Achievements |
From February 2020, we have been enrolling babies in the study. Till April 21, 2021, the total number of babies enrolled at 6 weeks of age in this study is 404.
Similarly, according to the study plan, we have been following them up. We have been collecting the nasopharyngeal samples of the babies at 6 weeks, 9 months, and 12 months of age.
Manuscripts of two projects which were partially funded by this grant in Nepal have been published. Besides, a manuscript regarding the study protocol of the study is ready for submission to an international journal.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Due to Covid-19, the research project has been affected very much. We could not enroll the expected number of children. We had to stop the enrollment for 2 months in 2020 fiscal year at the peak of number of Covid-19 cases. The government has implemented policies to decrease transmission of the virus, including the restriction of travel. Therefore, number of children visited to the hospital has decreased dramatically.
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| Strategy for Future Research Activity |
We plan to stop enrolling the children once the number of enrolled children reach 500. We will keep following up them till 15 months of age.
For laboratory procedure, at first we will start extracting DNA from the nasopharyngeal samples collected at the 6 weeks of age. Then, according to completion of the follow ups, we will extract DNA and plan for detection of pneumococcus and other pathogens.
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| Causes of Carryover |
Due to Covid-19, the research could not be carried out as planned. I could not go to Nepal to observe the research. The remaining fund is planned to be used in the payment of the publication fee and buying research materials, e.g., a CLSI guideline, a laptop, and barcode printing paper.
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Research Products
(5 results)
