Development of a new topical agent for psoriasis vulgaris.

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Aichi Medical University
• Principal Investigator: Hiroyuki Takama 愛知医科大学, 医学部, 講師 (80780965)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: EGFR

Outline of Final Research Achievements

We reported on the role of keratinization of disease-specific genes in skin diseases and their treatment. We reported that the NIPAL4 gene is involved in the metabolism of acylceramide in the stratum corneum and that IL-17 and IL-36 are involved in the pathophysiology of the mutation. We reported two cases of nail psoriasis, who were successfully treated with corticosteroid and vitamin D3 analogue in topical gel formulation.

Free Research Field

皮膚科

Academic Significance and Societal Importance of the Research Achievements

角化症やその他の皮膚疾患の病態解明、新たな治療法の解明などにつながる臨床症例経験や、遺伝子関連疾患の皮膚での役割を報告することができた。