2019 Fiscal Year Final Research Report
Analysis of oxidative stress in the brain in Alzheimer's disease model mice and establishment of bone marrow mesenchymal stem cell therapy
| Project/Area Number |
17K16388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 間葉系幹細胞 / アルツハイマー病 / 認知症 / 酸化ストレス / ミクログリア / アミロイドβ |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSC) has a therapeutic potential for Alzheimer's disease (AD) targeting various mechanisms including neuroprotective, immunomodulatory, and antioxidant action. The purpose of this study is to clarify the effect and treatment mechanism of MSC treatment on AD model mice. Transplantation of MSC ameliorated amyloid beta pathology in AD model mice through modifying amyloid beta clearance by microglia and improving the unbalanced redox status of the AD model mouse brain, thereby improving cognitive function.
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| Free Research Field |
神経内科
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| Academic Significance and Societal Importance of the Research Achievements |
札幌医科大学が中心となってすでに脳梗塞や脊髄損傷などの分野で自己骨髄間葉系幹細胞の経静脈的移植の臨床応用が開始されている。本研究ではアルツハイマー病に対する間葉系幹細胞による治療メカニズムの一端を明らかにすることができたと考えられ、将来のアルツハイマー病に対する病態抑制治療としての可能性を広げることができたと考えられる。
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