Radiosensitization by stem cell stherapy using metal nanoparticles

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16442
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: HARADA AYA 神戸大学, 医学研究科, 医学研究員 (50610284)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: Nanoparticle / Radiosensitization / Cancer

Outline of Final Research Achievements

Polyacrylic acid (PAA)-titanium peroxide nanoparticles (PAA-TiOxNPs) which were synthesized from commercial TiO2 nanoparticles and modified with PAA showed a distinct ability to enhance radiation effects in comparison to gold nanoparticles (AuNPs). PAA-TiOxNPs showed more tumor growth inhibition after intra-tumoral injection into MIAPaCa-2 human pancreatic cancer cells xenografted nude mice combined with by 5 Gy irradiation. PAA-TiOxNPs produces its radiosensitizing effects through the production of ROS (reactive oxygen species) mainly H2O2 (hydrogen peroxide). Absorption to mesenchymal stem cell were not observed.

Free Research Field

放射線腫瘍学

Academic Significance and Societal Importance of the Research Achievements

過酸化チタンナノ粒子は金ナノ粒子と比較して、ROSの産生などの観点から、難治癌に対する治療戦略の中でより有望な候補物質といえる。動物実験では、腫瘍増殖抑制効果が認められたが、今後前臨床試験や臨床試験への移行するためには、ナノ粒子の均一な製造方法や表面修飾方法を更に検討していく必要があると思われる。