Study on constructing novel prediction model for adverse events following radiation therapy for head and neck cancer

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16501
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka International Cancer Institute
• Principal Investigator: Hirata Takero 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 特別研究員 (20777916)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 高精度放射線治療 / 有害事象予測

Outline of Final Research Achievements

In this study, we aimed to establish prediction models for hypothyroidism, xerostomia and dysgeusia following intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) for head and neck cancer. We demonstrated a prediction model for hypothyroidism based on the median thyroid dose. This model is applicable to radiotherapy planning for patients with head and neck cancer. We could not reveal any predictive factors for xerostomia or dysgeusia. Future studies are necessary to construct a risk model for xerostomia or dysgeusia.

Free Research Field

放射線科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、甲状腺機能低下症の発症リスク低減を目指した個別化放射線治療計画（甲状腺に照射される放射線量の制約の設定）に応用可能であり、臨床導入により対象患者の利益に直結するものである。