Influence of Fc gamma receptor gene polymorphisms on antibody dependent cellular cytotoxicity in organ transplantation

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16508
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: National Center for Child Health and Development (2018); Hiroshima University (2017)
• Principal Investigator: Seiichi Shimizu 国立研究開発法人国立成育医療研究センター, 臓器移植センター, 医師 (90781021)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 抗体関連拒絶反応 / 遺伝子多型

Outline of Final Research Achievements

With respect to the IgG subclass analysis of pre-existing donor specific antibody (preformed DSA) and donor non-specific antibody (non DSA), it is possible to identify the dominant subclass which contained in serum by flow cytometric analysis. By Using this method, kidney transplantation could be performed after desensitization for cross-match positive cases and highly sensitized cases. However, it was difficult to identify the subclass of DSA by luminex detection method.

Free Research Field

臓器移植

Academic Significance and Societal Importance of the Research Achievements

FCGR2A, FCGR3Aの一塩基多型と、肝臓及び腎臓移植後の抗体関連拒絶反応(AMR)による移植臓器機能障害の進行度および組織傷害の程度との関連を解明することで、preformed DSA症例や術前クロスマッチ陽性症例においてAMRを引き起こす移植臓器傷害の高危険症例が同定され、肝および腎移植術後におけるAMRの予防・治療の個別化医療が可能となることが期待される。