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2018 Fiscal Year Final Research Report

Analysis of S100 family proteins and exosomal microRNA in duodenal juice as a diagnostic marker of pancreatic ductal adenocarcinoma

Research Project

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Project/Area Number 17K16565
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

MORI yasuhisa  九州大学, 大学病院, 助教 (50632642)

Project Period (FY) 2017-04-01 – 2019-03-31
Keywords膵癌 / 十二指腸液 / エクソソーム
Outline of Final Research Achievements

S100A2, S100A4, S100A6, and S100A11 concentrations in duodenal juice were measured using a ELISA kit. But the concentrations S100 family protein were not useful for detection of pancreatic ductal adenocarcinoma. We tried to extract exosomes from duodenal juice by ultracentrifugation. We successfully isolated exosomes from duodenal juice. Also we found exosomal RNA (miR-155) might be a biomarker of pancreatic ductal adenocarcinoma.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

膵癌は他癌と比較して極めて予後不良である。この理由として膵癌は早期には症状に乏しく、発見時には進行癌であることが多いことが挙げられる。このため早期発見と効果的なスクリーニング法の開発が求められるが、微小膵癌の段階で診断されるのは極めて稀である。低侵襲に採取可能な十二指腸液中の膵癌早期発見のマーカーを検出することができれば、膵癌を早期に発見することが可能となり、予後改善の足掛かりとなる可能性がある。

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Published: 2020-03-30  

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