cell therapy using functional gene-editing cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16569
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Nagasaki University
• Principal Investigator: KOBAYASHI Shinichiro 長崎大学, 病院(医学系), 助教 (80623363)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 食道狭窄 / 再生医療 / 高度炎症

Outline of Final Research Achievements

There were several treatments by cell therapies uisng tissue-enginnering. However, the effectiveness of the cell therapies was limited in the severe inflammatory condition . Thus, it is necessary to develop the novel cell therapy for the severe inflammatory condition.In this study, anti-innflammatory cytokine help to keep the normal conditon after injury. The specific gene transfer was tried in the several experiments. The gene-editing technique gave the influence about viability and growth of epithelial cells. Nowaday, we have develop the novel gene editing protocol.

Free Research Field

細胞治療

Academic Significance and Societal Importance of the Research Achievements

これまでの治療学は病巣を切除するのみであり、治癒に関しては、生体の反応に委ねていた。そのため、一定の確立で合併症が発症してしまう。細胞治療、再生医療は治癒を促進できる治療法として注目されている。本研究により、抗炎症性因子が創傷治癒に与える影響が示唆された。低侵襲治療の基盤となる理論が確認できたため、創薬の基盤となるだけでなく、細胞治療として新たな医療となる可能性が示唆された。