• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

To verify the molecular mechanism of pancreatic cancer progression related with chronic inflammation via cancer stem cell expansion.

Research Project

  • PDF
Project/Area Number 17K16570
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

ARIMA Kouta  熊本大学, 医学部附属病院, 非常勤診療医師 (10792616)

Project Period (FY) 2017-04-01 – 2019-03-31
Keywords慢性炎症 / 癌幹細胞 / 全トランスレチノイン酸 / 膵臓癌
Outline of Final Research Achievements

Chronic inflammation which has affected a lot of cells, such as immune cell and cancer stem cell (CSC), is a risk factor of many cancers, however, they have not been applied clinical application yet due to complicated interactions. The current study showed to identify the critical CSC marker in pancreatic cancer and new tumor -progressing mechanism via expanding CSC fraction. In addition, we found that ATRA (all-trans retinoic acid) could be a therapeutic reagent for the patients whose tumor is accumulated prostaglandin E2 due to chronic inflammation.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

膵癌は最も難治性の消化器癌の1つであり、有効な抗がん剤治療は数少なく効果も乏しいのが現状である。本研究では、慢性炎症に起因したATRAの枯渇を介した膵癌増殖の新規メカニズムを明らかにした。ATRAが白血病治療薬として使用されるようになってから白血病治療は劇的に進化したが、固形癌においては未だ有効な効果が得られた癌腫はない。本研究で明らかにしたようなメカニズムの影響が強い膵癌症例に限定することで、ATRAが膵癌に対して有効な新規治療薬なり得る。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi