Development of treatment for cholangiocarcinoma with miRNA delivered by super carbonate apatite nanoparticle

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16574
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: Muto Makoto 福島県立医科大学, 医学部, 助手 (10791478)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 胆道癌 / miRNA

Outline of Final Research Achievements

The aim of this study is to search the tumor suppressive miRNA of cholangiocarcinoma and to show the effectiveness of in vivo administration by super carbonate apatite nanoparticle.During the research period, the tumor suppressive miRNAs were narrowed down by miRNA microarray with cholangiocarcinoma tissue. Possible miRNAs were induced into cholangiocarcinoma cell line to evaluate proliferation ability. As a result, induction of miR-x1 and miR-x2 showed tumor suppressive effect. Further research in vitro and evaluation of in vivo administration is being planned.

Free Research Field

肝胆膵外科

Academic Significance and Societal Importance of the Research Achievements

現在の切除不能、再発胆管癌に対する抗癌剤治療は、ゲムシタビン、シスプラチンを主軸とした化学療法が中心であり、有効な治療法が限られている。本研究で胆管癌細胞株に対するmiR-x1、miR-x2の抗腫瘍効果を示したことにより、癌制御メカニズムの解明や新規抗癌治療開発に寄与し、胆管癌患者の予後を改善させる可能性を示した。