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2018 Fiscal Year Final Research Report

The role of alveolar macrophages in compensatory lung regeneration

Research Project

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Project/Area Number 17K16616
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionKeio University

Principal Investigator

KURIYAMA SHOJI  慶應義塾大学, 医学部(信濃町), 助教 (20768733)

Project Period (FY) 2017-04-01 – 2019-03-31
Keywords肺再生 / 呼吸器
Outline of Final Research Achievements

The purpose of this study was focusing on macrophages as a trigger for regeneration in compensated lung regeneration, phenotypic analysis of alveolar macrophages was performed using the left lung resection model in mice. However, no major changes could be observed in the macrophage fraction, and the plan was changed to exhaustively search for roles and changes in miRNA gene expression control by analyzing the miRNA array. Mir 200c involved in the expression of thyroid transcription factor-1 (TTF-1) was identified.

Free Research Field

呼吸器外科

Academic Significance and Societal Importance of the Research Achievements

今回代償性肺成長のkey regulatorと成りうる遺伝子発現制御機構としてmiRNAを同定した。機能解析・阻害実験が必要であるが今後代償性肺性の機能解析が進むことにより肺胞再生の新治療を樹立できる可能性がある。

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Published: 2020-03-30  

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