Development of Catheters for Neuroendovascular Therapy with Micro-Surface Shape

2022 Fiscal Year Final Research Report

• Project/Area Number: 17K16657
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Nagoya City University
• Principal Investigator: Nishikawa Yusuke 名古屋市立大学, 医薬学総合研究院(医学), 助教 (40625993)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Keywords: catheter coating

Outline of Final Research Achievements

The frictional force of the catheter against the vessel wall is reduced by the hydrophilic coating on the surface. The purpose of this study was to demonstrate whether this frictional force could be reduced by the surface microtopography of the catheter. However, corona disruption made it impossible to manufacture catheters with a fine surface profile. We therefore measured the coefficient of friction of catheters with hydrophilic coatings and verified the vascular geometry that was difficult to induce during this experiment. The results showed that in the aortic arch, inner catheter selection can be more accurately evaluated based on whether the level of the origin of the selected artery is lower than the level of the lesser curvature of the aortic arch compared with evaluation of the aorta type III.

Free Research Field

Neuroendovascular catheter

Academic Significance and Societal Importance of the Research Achievements

脳血管内治療において目的とする場所までカテーテルを誘導するためにはカテーテルの追従性は大きなかかわりをもつ。カテーテルが血管内を進む時にカテーテルと血管内壁が触れ、これによる摩擦がカテーテルの追従性を低下させている。これまで発売されているカテーテルは表面コーティングによって摩擦力低下が行われてきたが、必ずしも十分とは言えない。そこで本研究ではカテーテル表面に微細形状をつけて血管内壁との間にかかる摩擦力を軽減できないか検討を行うこととした。