Basic research of Kampo treatment for peripheral neuropathy by anticancer drug

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16717
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Sato Izumi 旭川医科大学, 大学病院, 医員 (70624196)
• Research Collaborator: KANDA Megumi ; KANDA hirotsugu ; ONODERA yoshiko ; ANNO eri
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 神経障害性疼痛 / 漢方治療

Outline of Final Research Achievements

We studied the effect of Go-sha-jinki-Gan (GJG) on HIV-induced allodynia using a rat model of HIV-related neuropathic pain. Neuropathic pain was induced by the application of recombinant HIV-1 envelope protein gp120 into the sciatic nerve. Mechanical threshold was tested using the von Frey filaments. Rats were randomly assigned to one of the following four groups: gp120 group, GJG-treated gp120 group, Sham group, and GJG-treated Sham group. The GJG-treated gp120 group showed improvement of allodynia as compared to the gp120 group.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

我々のデータは、HIV関連神経障害性疼痛ラットモデルにおいて牛車腎気丸がHIV誘発性アロディニアを抑制することを示した。これにより牛車腎気丸がHIV関連神経障害性疼痛に有効である可能性が示唆された。現在、HIV関連神経障害性疼痛に対して牛車腎気丸が作用する機序について、分子生物学的検討を行っている。