Effects of anesthetic agents on oxytocin induced contractions of the pregnant rat myometrium in vivo and in vitro

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16744
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Sapporo Medical University
• Principal Investigator: Kimizuka Motonobu 札幌医科大学, 医学部, 助教 (30758686)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 子宮筋収縮 / デクスメデトミジン / 帝王切開

Outline of Final Research Achievements

This study demonstrated that dexmedetomidine enhances oxytocin-induced contractions of pregnant rat myometrium more than propofol and sevoflurane. Inhibition of myofilament calcium sensitivity may have caused the inhibition of myometrial contraction by sevoflurane. Arachidonic acid may play an important role in the enhancement of myometrial contraction induced by dexmedetomidine through enhancing myofilament calcium sensitivity. Dexmedetomidine would be an advantageous anaesthetic agent during caesarean sections.

Free Research Field

麻酔科学一般

Academic Significance and Societal Importance of the Research Achievements

帝王切開中に使用する麻酔薬には子宮筋収縮を抑制する効果があり、弛緩出血などの原因とされてきた。しかし、今回の研究成果をもとに今後はデクスメデトミジンを帝王切開中の鎮静薬として使用することにより、今後弛緩出血を減らし、妊産婦死亡症例を減らすことができる可能性が示唆された。