2021 Fiscal Year Final Research Report
Effects of polymorphisms in the serotonin transporter promoter-Linked polymorphic region on incidence of chronic pain and the treatment.
| Project/Area Number |
17K16750
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2022-03-31
|
| Keywords | セロトニントランスポーター遺伝子 / 慢性痛 / 開胸術後疼痛症候群 / 帯状疱疹後神経痛 |
|---|
| Outline of Final Research Achievements |
Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. This study assessed the role of 5-HTTLPR polymorphisms in incidence of chronic pain and the treatment. This study suggests that polymorphisms in 5-HTTLPR is not associated with postthoracotomy pain severity. Furthermore, polymorphisms in 5-HTTLPR is not associated with postherpetic neuralgia pain severity and quality.
|
| Free Research Field |
麻酔科学
|
| Academic Significance and Societal Importance of the Research Achievements |
近年、セロトニントランスポーター（5-HTTLPR）遺伝子多型が鎮痛薬の効果や慢性痛発症と関連している可能性が示されているが、今回の一連の研究では、5-HTTLPR遺伝子多型単独でははっきりと術後の痛みから慢性的な痛みへの影響、帯状疱疹後神経痛の痛みの強さや性質への影響は見いだせなかった。慢性痛と遺伝的要因に関する研究はまだまだ少なく、今後このような研究の発展により痛みの個人差が明らかになり、痛み治療の進歩につながることが期待される。
|
