Elucidating the mechanism of mitochonria participation in the development of diabetic cystopathy. Is there a role of sirtuin 1 gene?

2018 Fiscal Year Annual Research Report

• Project/Area Number: 17K16793
• Research Institution: Tottori University
• Principal Investigator: ツナピ パナイオタ 鳥取大学, 医学部附属病院, プロジェクト研究員 (50767431)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: diabetes mellitus / antioxidants / sirtuin 1 gene / sirtuin 1 gene activator / resveratrol / taurine

Outline of Annual Research Achievements

Diabetes mellitus type-2 induced significantly increased levels of oxidative stress, both lipid peroxidation and DNA oxidative damage, in the bladder. This has as a result the degeneration and deconstruction of the bladder tissue, especially the urothelium and this further affected the proper function of the tissue in a negative way. By treating the animals with antioxidants, there was a significant decrease in the expression levels of the oxidative stress parameters and subsequently an improvement in the histology and the function of the tissue.
In our study it is of great value that we initiated the antioxidants treatment at an early stage of the diabetes. This resulted into more effective antioxidant treatment. The prompt diagnosis of diabetes can be crucial for the progression of the disease. Therefore our results indicate that antioxidants may have a beneficial effect in diabetic status and further research is necessary for their role as adjunct therapy.

Research Products

• [Presentation] Oxidative stress-related alterations in the bladder of a short-period diabetes type-2 rat model. (2018)
  • Author(s): Panagiota Tsounapi, Masashi Honda, Fotios Dimitriadis, Yusuke Kimura, Shogo Shimizu, Bunya Kawamoto, Katsuya Hikita, Motoaki Saito, Nikolaos Sofikitis, Atsushi Takenaka
  • Organizer: The Annual Meeting of the American Urological Association
  • Int'l Joint Research
• [Presentation] Can antioxidant therapy be protective against diabetes-induced bladder dysfunction? (2018)
  • Author(s): Panagiota Tsounapi, Masashi Honda, RyutaroShimizu, Ryoma Nishikawa, Shogo Teraoka, Yusuke Kimura, Tetsuya Yumioka, Noriya Yamaguchi, Hideto Iwamoto, Shuichi Morizan, Katsuya Hikita, Nkolaos Sofikitis, Atsushi Takenaka A.
  • Organizer: The Annual Congress of the European Association of Urology
  • Int'l Joint Research
• [Presentation] Changes in oxidative stress parameters in the bladder of a short-period diabetes type-2 rat model. (2018)
  • Author(s): Panagiota Tsounapi, Masashi Honda, Ryutaro Shimizu, Ryoma Nishikawa, Shogo Teraoka, Yusuke Kimura, Tetsuya Yumioka, Noriya Yamaguchi, Hideto Iwamoto, Shuichi Morizan, Katsuya Hikita, Nkolaos Sofikitis, Atsushi Takenaka A.
  • Organizer: The Annual Meeting of the Japanese Urological Association