New strategy for bladder cancer using atmospheric pressure plasma jet

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kochi University
• Principal Investigator: FUKUHARA Hideo 高知大学, 教育研究部医療学系臨床医学部門, 助教 (20527600)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 膀胱癌 / プラズマ医療 / アポトーシス

Outline of Final Research Achievements

Atmospheric pressure plasmas jets kill cancer cell not only directly, but also indirectly affected cancer cell with plasma-irradiated medium. Medium which APPJs was irradiated generated the several biochemical activities. Plasma-activated medium (PAM) induces especially ROS generation by complicated chemical reactions into medium. ROS is well-known to activate apoptosis signal cascades for various cancer cells. PAM treatment may become a potential therapeutic strategy for human bladder cancer as intravesical therapy.

Free Research Field

泌尿器腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、プラズマを用いた新しい治療法により膀胱癌対する良好な効果を認めた。今後は更なるメカニズムを解明し、膀胱癌に対する新たな膀胱温存療法の開発が大いに期待される。