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2018 Fiscal Year Final Research Report

Effect of NGAL on the inflammatory response

Research Project

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Project/Area Number 17K17067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKeio University

Principal Investigator

Inoue Kei  慶應義塾大学, 医学部(信濃町), 助教 (90464932)

Project Period (FY) 2017-04-01 – 2019-03-31
KeywordsNGAL / 敗血症
Outline of Final Research Achievements

We tested the hypothesis that NGAL, known as a potent immunomodulator, would improve the outcomes of rats with excessive inflammatory responses. We were unable to show the beneficial influence of NGAL on the outcome.

Free Research Field

麻酔学

Academic Significance and Societal Importance of the Research Achievements

本研究により腸管免疫機構以外への全身性のNGALの影響を明らかにし、創薬としての臨床応用への可能性を探求することで、感染症に対して必須なmultimodal approachの重要な柱の一つとなることで敗血症患者の治療戦略に一石を投じることを試みたが期待した結果は得られなかった。今後宿主条件やNGALの投与時期等の条件を検討して更なる探求することで上記を意義を見出していきたい。

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Published: 2020-03-30  

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